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Open access Oct 2026

TCASIA: an integrative atlas linking alternative splicing landscapes for cancer immunotherapy

Abstract Background Identifying robust predictive biomarkers for immune checkpoint blockade (ICB) remains a challenge. While alternative splicing (AS) shapes tumor immunity, the lack of large-scale, consensus-based datasets constrains the characterization of ICB-specific splicing landscapes. Methods We developed TCASIA...

Yi-Hao Zhang, Yun-Zhi Guo, Hai-Tao Wang et al. · 0 citations
Open access Sep 2026

DDX21 Enhances Radiosensitivity in Head and Neck Squamous Cell Carcinoma by Suppressing MK2‐Mediated DNA Damage Response

ABSTRACT Radioresistance remains a significant challenge in the radiotherapy (RT) of head and neck squamous cell carcinoma (HNSCC). However, the biological factors that govern sensitivity to this therapy are not well‐understood. The DEAD‐box family is known for its role in genome stability, and inextricably linked to t...

Tian-Ru Yang, T. Shen, Yan-Fang Qiu et al. · 0 citations

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