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Open access Oct 2026

Machine learning and multi-omics analyses reveal CLDN1 as a candidate marker associated with colorectal cancer invasion and nutlin-3a (-) response.

OBJECTIVE Colorectal cancer (CRC) is molecularly, cellularly and spatially heterogeneous, and current staging systems and biomarkers incompletely explain prognosis and treatment response. This study integrated transcriptomics, machine learning, single-cell RNA sequencing, spatial transcriptomics and in vitro experiment...

Wenqi Shan, Qian-Yu Li, Wei Yuan et al. · 0 citations
Sep 2026

Comprehensive Pain Management, Quality of Life, and Mental Health in Advanced Cancer: A Propensity Score-Matched Retrospective Study.

For advanced cancer patients, unrelieved moderate-to-severe pain adversely affects quality of life and psychological well-being. While pain control is fundamental to palliative care, the benefits associated with a multimodal approach warrant investigation. This PSM-based retrospective study (2022-2025) evaluated the as...

Wen-Fang Lei, Yan-Mei Gao, Wei Yuan et al. · 0 citations

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