Open access
Sep 2026
Gut microbiota dysbiosis aggravates liver injury in acute-on-chronic liver failure through D-lactate accumulation
Introduction Acute-on-chronic liver failure (ACLF) is a life-threatening condition arising from the abrupt worsening of pre-existing chronic liver disease, typically accompanied by multi-organ failure and markedly elevated short-term mortality. Gut microbiota dysbiosis is frequently observed in patients with ACLF, yet...
Zhi-Wu Zeng, Li-Ning Xu, Ming-Qing Yang et al.
· Frontiers in Microbiology · 0 citations