Systemic autoimmune rheumatic diseases (SARDs) are chronic, heterogeneous disorders in which loss of immune tolerance, persistent inflammation, and tissue-specific injury can culminate in irreversible organ damage and fibrosis. Although glucocorticoids, conventional immunosuppressants, biologics, and targeted small...
Hong-Hao Guo, Wang Xiang, Liu-Ting Zeng et al.· Frontiers in Immunology· 0 citations
Persistent autoantibody production after conventional immunosuppression or B-cell depletion has focused attention on antibody-secreting cells that survive without ongoing proliferation. Long-lived plasma cells (LLPCs) are indispensable for durable protective immunity, but autoreactive members of this compartment may al...
Hong-Hao Guo, Wang Xiang, Liu-Ting Zeng et al.· Autoimmunity Reviews· 0 citations
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