Wei-Wei Zhang

A regenerating free-energy register for protein-templated period-2 DNA synthesis by Drt3b

Deng et al. discovered that Drt3b synthesizes protein-primed poly(AC) DNA without a nucleic-acid template. The structures reveal a finite protein architecture and product-associated contacts, but not the renewable dynamical rule that converts a bounded pocket into a long period-2 sequence. We propose that Drt3b is a re...