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Sep 2026

Proteome-wide Mendelian randomization and transcriptome analysis of a novel osteoarthritis blood-targeting USP8, single-cell model and experimental validation.

This comprehensive genome-wide association meta-analysis revealed new OA-related variants and several blood proteins with possible causal relationships with OA that can contribute to a deeper understanding of the genetic basis of this disease and suggest OA-related pathways as promising targets for further therapeutic...

Qi-Wang He, Yue Liu, Xi-Ming Liu et al. · 0 citations
Jul 2026

Exploring the Potential Mechanism of Isoliquiritigenin in the Treatment of Osteoarthritis through Integrated Network Pharmacology, Molecular Docking, and Experimental Validation.

INTRODUCTION Osteoarthritis (OA) is a prevalent and chronic joint disease characterized by progressive cartilage degeneration and chronic inflammation. Isoliquiritigenin (ISL), a bioactive flavonoid derived from licorice, has demonstrated significant anti-inflammatory potential in various diseases. However, its specifi...

Wei Wang, Qiwang He, Zhiwen Zhang et al. · 0 citations

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