Author

Wei Wang

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Open access Jul 2026

Miniaturizing and modifying natural proteins with Raygun.

Raygun is introduced, a generative artificial intelligence framework that enables miniaturization, modification and augmentation of proteins, using a probabilistic encoding of protein sequences constructed from language model embeddings, enabling the kind of coordinated, large-scale sequence modifications that characterize natural protein evolution.

Kapil Devkota, Daichi Shonai, Joey Mao et al. · Nature · 1 citation

Open access Aug 2026

A blinded, prospective benchmark of in silico antibody discovery anchored to experimental affinity and developability.

The AIntibody challenge shows that AI can optimize antibodies in defined, biologically grounded regimes, in addition to highlighting critical gaps including affinity prediction and library-inspired antibody design and cross-task generalization.

M. Erasmus, Daniel Bedinger, Elizabeth Hopkins et al. · Nature Biotechnology · 0 citations