Sciadopitysin Attenuates Ovariectomy-induced Bone Loss via Restoration of the OPG/RANKL Axis and Suppression of Inflammatory Signaling
Postmenopausal osteoporosis (PMO) is primarily caused by estrogen deficiency, which disrupts physiological bone remodeling by enhancing osteoclast-mediated bone resorption while suppressing osteoblast-mediated bone formation. These changes promote a pro-inflammatory microenvironment, accelerate skeletal deteriorati...