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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Weike Ji

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2 papers indexed here

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Open access Oct 2026

A FIT2–BLTP1 module sustains lipid droplet phosphatidic acid and restrains overgrowth

Lipid droplets (LDs) are assembled at discrete endoplasmic reticulum (ER) subdomains whose local phospholipid composition, rather than their protein content alone, determines whether a LD nucleates and how large it grows. Phosphatidic acid (PA) is the pivotal lipid of this environment, yet how PA reaches a forming LD h...

Qing-Zhu Chu, Tian-Tian Zhou, Zhao-Ming Zhou et al. · 0 citations
Aug 2026

BLTP2 bridges the ER and MVB for exosome biogenesis at SCAMP3-dependent ER contacts.

Multivesicular bodies (MVBs) contain intraluminal vesicles (ILVs) designated for degradation in lysosomes or release as exosomes for cell-to-cell communication. The mechanisms governing ILV/exosome formation are not fully understood. Here, we show that the integral endoplasmic reticulum (ER) membrane protein bridge-lik...

Jingru Wang, Dongchen Li, Yazhou Liu et al. · 0 citations

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