Integrated UHPLC-MS/MS and DrugCIPHER-Based Network Pharmacology to Identify Signature Components and Evaluate Pharmacokinetics of Biyuan Tongqiao Granules in Rats.
Biyuan Tongqiao Granules (BTG) is commonly used TCM formula for the clinical treatment of acute rhinosinusitis (ARS). However, the systemic identification of its plasma-absorbed components and metabolites, as well as the pharmacokinetic profiles of its pharmacodynamically relevant signature compounds, remains poorly ch...