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Author

Wei-Hua Fu

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Open access Oct 2026

FLNA Expression in Cancer-Associated Fibroblasts Is Associated with Immunosuppression and Tumor Progression in Colorectal Cancer

Background The role of Filamin A (FLNA) in colorectal cancer (CRC), particularly within the stromal compartment, remains poorly defined. This study investigates its expression, function, and clinical relevance in CRC. Methods We integrated transcriptomic data from the GSE39582 training cohort and TCGA/GSE75316 validati...

Q. Yao, Ning-Bo Liu, Shi-Long Li et al. · 0 citations
Open access Sep 2026

RIPK3 overcomes 5-fluorouracil resistance in colorectal cancer cells via AKT/mTOR-mediated autophagy

RIPK3 enhances the sensitivity of colorectal cancer cells to 5-FU and increases the efficacy of 5-FU in inhibiting cell proliferation, invasion, and migration by activating cellular autophagy through inhibition of the AKT-mTOR signaling pathway, thereby reversing drug resistance in colorectal cancer cells.

Biao Wang, Xiao-Tong An, Wei-Hua Fu · 0 citations

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