Wei-Hong Tan

Functional Nucleic Acid-Antibody Conjugates for Effective Tumor Targeted Therapy With Controllable Side Effects.

Antibody-guided therapeutics, including antibody-drug conjugates and radiopharmaceuticals, efficiently deliver payloads to tumor lesions, but the weeks-long half-life of antibodies promotes accumulation in normal tissues, increasing the risk of off-target toxicity. Although conventional linkers generally provide system...