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Author

Wei Gu

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Open access Sep 2026

Targeting the ChREBP/PKLR-lactate axis via Huachansu tablets restores CD8⁺T cell immunity in MASH-HCC.

The incidence of metabolic dysfunction-associated steatohepatitis-related hepatocellular carcinoma (MASH-HCC) continues to rise worldwide, highlighting an urgent need for effective therapies. Natural products represent a vital source for anticancer drug discovery. Huachansu tablets (HCS), a clinically approved adjuncti...

Yue-Yue Li, Jing-Jing Ma, Wei-Tong Peng et al. · 0 citations
Open access Aug 2026

Whole-genome resequencing with multidimensional annotation revealed pathogenic networks in sirenomelia

The findings support a multilayered pathogenic model in which genetic variants collectively disrupt the core developmental pathways involved in posterior axis formation, vasculogenesis, and organogenesis and identify potential targets for future research and clinical applications.

Zefeng Zhu, Wanting Hao, Ziyu Wan et al. · 0 citations

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