Physics in Medicine & Biology
Jing-Hui Wang, Ming-Qing Wang, Heng Wang et al.
· 0 citations
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Open access
Jun 2026
The structural basis for LRRK2’s activation and autoinhibition
Using cryo-EM, biochemical reconstitution, and cell-based assays, it is shown that the ROC GTPase governs switching between autoinhibited and active states: GTP binding promotes activation, whereas GDP binding enforces autoinhibition.
Amalia Villagran Suarez, Kathryn S. Hatch, Tatyana Bodrug et al.
· bioRxiv · 1 citation
Open access
Aug 2026
The structural basis for LRRK2's activation and autoinhibition.
A unified framework for understanding LRRK2 regulation with broad therapeutic implications is provided, showing that the ROC GTPase governs switching between autoinhibited and active states: GTP binding promotes activation, whereas GDP binding enforces autoinhibition.
Amalia Villagran Suarez, Kathryn S. Hatch, Tatyana Bodrug et al.
· Cell · 0 citations