Author

Wei-Dong Xiao

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Open access Oct 2026

Integrative transcriptomic and computational analysis associates Ms4a6c+ macrophages with fibrosis in radiation proctitis and computationally nominates MOTS-c as a candidate modulator

Background Chronic radiation proctitis (CRP) represents a significant clinical challenge characterized by irreversible fibrosis and a lack of specific pharmacological interventions. This study aimed to elucidate the cellular mechanisms underlying impaired tissue repair to identify novel therapeutic targets. Methods We...

Peng Wang, Wei Tao, Hong Wen et al. · Frontiers in Immunology · 0 citations

Open access Aug 2026

Macrophage PABPC4‐SPP1 Axis Orchestrates Immunosuppression in Colorectal Cancer

It is identified that PABPC4, a member of PABPs, is upregulated during colorectal cancer progression and associated with poor prognosis, and a previously undiscovered PABPC4‐SPP1 axis in macrophages is revealed, which induces tumor‐promoting macrophages and CD8+ T cell dysfunction, thereby facilitating tumor progressio...

Meng Wang, Fang Yang, Yuan Gao et al. · Advancement of science · 0 citations