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Open access Sep 2026

Plasma Proteome-Wide Mendelian Randomization with Multi-Layer Triangulation Identifies Druggable Targets for Uterine Leiomyoma

Background Uterine leiomyoma (fibroids) is the most common benign tumor in women and the leading indication for hysterectomy, yet medical therapy remains limited and largely hormonal. Whether circulating proteins causally influence fibroid risk, and could therefore be repurposed as drug targets, has not been examined p...

Xin Wang, Guang-Lei Yao, Wei Ding · 0 citations
Open access Aug 2026

Interpretable machine-learning risk stratification at the time of diagnosis for 3-year mortality in de novo metastatic prostate cancer: development and temporal validation in SEER

Men with de novo metastatic prostate cancer (mPCa) face a poor but heterogeneous prognosis, yet interpretable, transparently reported diagnostic-time tools remain limited. Using the Surveillance, Epidemiology, and End Results (SEER) 17-registry database (2010–2020), we developed and temporally validated machine-learnin...

Xin Wang, Guang-Lei Yao, He-Qian Liu et al. · 0 citations

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