Wei Deng

Asymmetric Dipolar Cycloadditions toward Chiral Medium-Sized Rings under Palladium and Iridium Catalysis.

Chiral medium-sized rings, defined herein as 7- to 11-membered cyclic frameworks, are common in bioactive molecules and occupy an important but still underexplored region of drug-like chemical space. Their asymmetric synthesis remains formidably challenging, as conformational flexibility, transannular interactions, and...