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Open access Sep 2026

SMC1A is required for fate determinations of human spermatogonial stem cells and male fertility by interacting with YBX1 and stabilizing HMGA2 mRNA via an m5C modification.

Spermatogonial stem cells (SSCs) are required for initiating and maintaining normal spermatogenesis, and notably, they have significant applications in both reproductive and regenerative medicine owing to their great plasticity with de-differentiation and trans-differentiation potentials. Nevertheless, molecular mechan...

Wei Liu, Li Du, Yan Zhu et al. · 0 citations
Review Oct 2026

Role of sirtuin 7 (SIRT7) in hepatic physiology and pathophysiology: mechanism, prospective and therapeutic potential.

Sirtuin 7 (SIRT7) is member of the oxidized nicotinamide adenine dinucleotide (NAD+)-dependent sirtuin family of proteins that participate in the regulation of a broad spectrum of biological processes and play central roles in cellular homeostasis. Compared with other sirtuins, SIRT7 has been less studied but has emerg...

Wei Chen, Dai-Fei Yang, Huai-Tian Liu et al. · 0 citations

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