Author

Wee-Joo Chng

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Open access Aug 2026

AI4Loop: an Artificial Intelligence Framework Reveals Increased 3D Chromatin Interactions and Therapeutic Vulnerabilities across 12,000 Cancer Samples

Three-dimensional chromatin interactions shape gene regulation, but their large-scale analysis remains limited by the cost and complexity of experimental assays. Here we present AI4Loop, a deep learning framework that infers genome-wide gene-centered chromatin interaction networks directly from RNA-seq data. Across mul...

Fu-Ying Dao, Benjamin Lebeau, Prachi Amuley et al. · bioRxiv · 0 citations

Jul 2026

Abstract P15: Context-aware foundation model of bulk transcriptomics for interpretable analysis of transcriptional dynamics and treatment response in AML

A context-aware foundation model of bulk transcriptomics for interpretable analysis of transcriptional dynamics and treatment response in AML, which establishes the model as a powerful framework to extract useful information from bulk transcriptomics data and has potential applications in precision medicine by connecti...

Yi-Bo Chai, Yang Li, Jianbiao Zhou et al. · Cancer Research · 0 citations