Aug 2026
LZTFL1 rewires NADPH-glutathione metabolism to amplify ferroptosis.
Ferroptosis, a form of oxidative cell death, represents a therapeutic vulnerability for treating apoptosis-resistant cancers. Here, we identify leucine zipper transcription factor-like 1 (LZTFL1) as a key regulator of ferroptosis that rewires glutathione (GSH) metabolism. Mechanistically, LZTFL1 promotes oxidation of g...
Xiangfei Xue, Xiao Zhang, Qianjun Zhou et al.
· Molecules and Cells · 0 citations