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This work introduces PROTEAN, a standardized benchmark for text-guided protein structural editing and provides an open testbed for developing autonomous, multi-backend macromolecular design agents.
A key challenge in bringing embodied intelligence into the real world is transferring capabilities from simulation to reality and enabling agents to continually adapt after deployment. End-to-end vision-language-action policies provide strong manipulation capabilities, but their transfer to physical environments typica...
Time-series foundation models (TSFMs) enable zero-shot forecasting through large-scale cross-domain pretraining, while retrieval augmentation further improves their performance by leveraging historical information. However, existing methods typically correct TSFM forecasts using the ground-truth futures of similar hist...
Experiments on multiple symbolic regression benchmarks show that SymbolicLM substantially improves structural recovery while maintaining competitive numerical fitting performance, demonstrating that symbolic regression can be explicitly learned as an intrinsic capability of LLMs.
This work designs five types of multimodal tasks across text, molecular SMILES strings and images, and curates the datasets, demonstrating the feasibility of unifying multiple cross-modal chemical tasks within a single foundation model and enabling more intuitive, visual human-AI interaction.
StraTA is a simple framework that introduces an explicit trajectory-level strategy into agentic reinforcement learning (RL) and trains strategy generation and action execution jointly with a hierarchical GRPO-style rollout design, further enhanced by diverse strategy rollout and critical self-judgment.
An injectively aligned leave-one-cell-out protocol over support x operation grids and SO-OPF, a readout that factors cell energy into support salience and a competitive operation posterior, and a readout that factors cell energy into support salience and a competitive operation posterior are introduced.
Powder X-ray diffraction (PXRD) is the routine probe of crystalline matter, yet its analysis is the rate-limiting step as laboratories automate acquisition. Deep-learning analyzers excel on simulated patterns and degrade on measured ones. This simulation-to-real gap is structural, not additive: synthetic denoising give...
JEPA-Anything, a domain-agnostic framework based on orthogonal predictive factorization (OPF), achieves the lowest one-step and 100-step molecular errors among compared methods in all four systems and supports a common factorized predictive principle across heterogeneous worlds.
Immune therapies act across cell-intrinsic programs, tissue ecosystems, and patient-specific immune states, yet most predictors address these scales separately. We used a governed evolutionary AI Scientist to construct the Immune World Model, an action-conditioned model that learns how interventions move immune states...
CENO is introduced, a family of long-context generative genomic world models designed to preserve local DNA grammar while extending usable context to regulatory and chromatin scales and provides a genome-scale sequence world-model framework for sequence interpretation, evolutionary reasoning, gene-scale reconstruction...
SciOrch is presented, a framework that trains a lightweight 8B model to orchestrate frontier LLMs for scientific reasoning, and attains the best accuracy on both SGI and SFE with less than half the API cost of typical multi-agent methods.
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