Evidence is synthesized on various PTMs such as phosphorylation, ubiquitination, SUMOylation, acetylation, methylation, glycosylation, S-nitrosylation, and metabolite-coupled modifications, including lactylation and succinylation that have the potential to enhance biomarker-guided disease stratification and inform the...
This paper systematically discusses the potential application value of ferroptosis-related protein PTM in overcoming tumor immune escape, enhancing the antitumor activity of T cells and natural killer cells, and improving the clinical efficacy of immune checkpoint inhibitors (ICIs).
Xin Xie, Li-Zhou Song, Zhao-Yu Li et al.· International Journal on Bio...· 0 citations
Chronic inflammation is now recognized as an important factor linking tissue damage to the development of cancer. Epidemiological studies have suggested that 20%-25% of cancers are related to chronic inflammation, as exemplified by chronic hepatitis B infection inducing hepatocellular carcinoma (HCC) or Helicobacter py...
Wangzheqi Zhang, Li-Zhou Song, D. Sandai et al.· Critical reviews in clinical...· 0 citations
This review systematically investigates the distinct functional states and biological behaviors of the cGAS-STING pathway under a variety of disease conditions to provide comprehensive theoretical references and research directions for follow-up basic mechanistic studies and clinical transformation of cGAS-STING target...
Minjue Shan, Yan Liao, Zi-You Lin et al.· Apoptosis· 0 citations
Neuroinflammation represents a common pathological mechanism underlying a wide range of central nervous system (CNS) disorders, encompassing neurodegenerative disorders (NDDs), ischemic stroke (IS), traumatic brain injury (TBI), and demyelinating diseases such as multiple sclerosis (MS). This process is initiated by th...
