Two-stage integrated evidence synthesis: Systematic review and meta-analysis of hyperbaric oxygen therapy for frostbite plus exploratory development of frostbite amputation risk prediction model using MIMIC-IV and eICU-CRD databases
## Study Objective This two-stage integrated study aims to address the unresolved clinical question: which patients with severe frostbite may benefit from adjunctive hyperbaric oxygen therapy (HBOT). Stage 1 will synthesize existing clinical evidence of HBOT for acute frostbite via systematic review and meta-analysis....