Author

Wan-Tao Wu

3 papers indexed here

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Review Open access Sep 2026

Biomimetic Scaffold‐Based 3D Models for Decoding Cancer Biology and Advancing Therapy

While conventional two‐dimensional (2D) cultures and animal models remain essential tools, they frequently fail to recapitulate the three‐dimensional (3D) architecture, biomechanical cues, and spatial complexity of human tumors, thereby limiting their translational relevance. To address these limitations, scaffold‐base...

Hai-Tao Zhao, Yue-Chen Han, Jie Li et al. · Advancement of science · 0 citations

Open access Aug 2026

Crosstalk Between CTSB+ Glioblastoma Cells and S100A10+ Macrophages: A Self‐Reinforcing Circuit Promotes Immune Evasion and Limits Response to Immunotherapy

ABSTRACT Background: Glioblastoma (GBM) establishes a highly immunosuppressive microenvironment through intricate molecular dialogues with tumor‐associated macrophages (TAMs), contributing to immunotherapy resistance. Methods: We integrated advanced biological network analyses with multimodal AI to identify CTSB as a k...

Hao Zhang, Nan Zhang, Xisong Liang et al. · Advancement of science · 0 citations

Open access Jul 2026

Integrative single-cell and spatial transcriptomic analysis reveals a lactate-driven crosstalk between NFATc4⁺ tumor cells and SPP1⁺ macrophages in glioblastoma

In vitro functional assays confirmed that NFATc4 knockdown in GBM cells suppressed tumor cell proliferation, migration, and cell cycle while promoting apoptosis, confirming the functional relevance of the NFATc4–SPP1 axis.

Ruo-Li Wang, Wan-Tao Wu, Xuan Wu et al. · Journal of Translational Med... · 0 citations