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Author

Walter Kolch

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2 papers indexed here

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Open access Oct 2026

SMAD3-driven cell state transitions underpin immunoresistance in bladder cancer

Despite the clinical success of anti-PD-1/PD-L1 immunotherapy in a subset of patients with high-risk bladder cancer (BLCA), most tumors remain refractory to treatment. We hypothesized that immunotherapy resistance is encoded within the intrinsic signaling state of BLCA cells and arises through specific cell-state trans...

Sarah Y. T. Robertson, J. Yang, Neil O. Carragher et al. · 0 citations
Open access Oct 2026

Multiomic characterization of microsatellite-stable colorectal cancer reveals distinct biology and targetable vulnerabilities.

Microsatellite-stable (MSS) colorectal cancer (CRC) is a molecularly complex and clinically challenging disease subtype, lacking effective targeted therapies. Leveraging multiomic data from ∼2,000 tumor samples (including 316MSS CRCs not previously profiled) representing ∼4,500 molecular profiles and 195,246 single cel...

A. Sadanandam, A. O'Farrell, I. Miller et al. · 1 citation

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