Author

Walid T. Khaled

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Open access Oct 2026

Tumor digital twins uncover therapeutic strategies in triple-negative breast cancer.

Triple-negative breast cancer (TNBC) is an aggressive malignancy with limited therapeutic options and a high risk of relapse and mortality. Consequently, there is a critical need for personalized treatment strategies that reflect the unique biology, clonal architecture, and evolutionary dynamics of individual tumors. H...

P. Victori, Kui Hua, Alecia-Jane Twigger et al. · Cell Reports Medicine · 0 citations

Open access Jul 2026

Combinatorial screening of biological degrader modules identifies heterobifunctional molecules that efficiently destroy MYC, leading to rapid tumour cell death in vitro and in vivo

Targeted protein degradation is a potent strategy against intracellular proteins impervious to traditional drugs. We describe a platform reliant on high-throughput cloning and mRNA-based delivery to quickly screen 100s-1000s of modular biological degraders, which we challenge against the high-turnover c-Myc oncoprotein...

C. Ascanelli, Samuel Gilberto, C. Batho et al. · bioRxiv · 0 citations