This study involved the design, synthesis, and comprehensive biological evaluation of a new library of 4H-pyran-pyrazole hybrid molecules. The compounds were synthesized via versatile multicomponent and cyclocondensation reactions and characterized using spectroscopic techniques. Their biological potential was assessed...
Salwa Aljohani, S. Zaki, Asma Obaidallah Alatawi et al.· Bioorganic chemistry (Print)· 0 citations
AIMS
This study aimed to design, synthesize, and evaluate novel benzanilide derivatives as potential anticancer agents targeting VEGFR-2-mediated tumor angiogenesis.
MATERIALS AND METHODS
Eight benzanilide derivatives (7a-e, 9a-b, and 11) were synthesized and structurally confirmed using spectroscopic methods. The co...
A. Metwaly, Hazem Elkady, Walid E. Elgammal et al.· Future Medicinal Chemistry· 0 citations
Experimental and computational findings identify compound 17 as a promising and mechanistically well‐characterized VEGFR‐2 inhibitor, warranting further in vivo investigation.
Hazem Elkady, Aisha A. Alsfouk, E. Elkaeed et al.· Archiv der Pharmazie· 0 citations
Mechanistic studies revealed that compound 7e induced significant apoptosis, promoted S-phase cell cycle arrest, and effectively inhibited cell migration in HCT-116 cells, identifying him as a promising dual VEGFR-2/CDK6 inhibitor with potent and selective anticancer activity.
Hazem Elkady, Walid E. Elgammal, I. Eissa et al.· RSC Advances· 0 citations
This integrated study pinpointed ACEB-Cl as a promising VEGFR-2targeted anticancer lead compound with strong inhibitory potency, and a clearly defined mechanism of action, supporting its progression for further improvement.
A. Metwaly, I. Eissa, Walid E. Elgammal et al.· Journal of Computational Bio...· 0 citations
Findings identify compound 7e as a promising VEGFR-2-targeted anticancer lead with strong enzymatic inhibition, potent cytotoxicity, and a well-supported mechanistic profile integrating experimental and computational evidence.
A. Metwaly, Walid E. Elgammal, I. Eissa et al.· RSC Advances· 0 citations
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