Novel series of piperazinyl-thienopyrimidine acetamide derivatives (10a-l, 13a-b, and 16a) were rationally designed and synthesized as potential type II VEGFR-2 inhibitors based on the essential pharmacophoric features of sorafenib and the co-crystallized ligand in the VEGFR-2 crystal structure (PDB: 2OH4). The target...
Abdulrahman M. Saleh, Wagdy M. Eldehna, Mohamed R. Elnagar et al.· European journal of medicina...· 0 citations
A series of 13 novel 3-hydroxyindolin-2-one-benzo[4,5]imidazo[2,1-b]thiazole hybrids was designed, synthesized, and evaluated as potential anti-Alzheimer agents targeting monoamine oxidase B (MAO-B) and cholinesterases. The target compounds were obtained by condensing a benzo[4,5]imidazo[2,1-b]thiazole-based ketone wit...
Wagdy M. Eldehna, Ashraf K. El-Damasy, Jaeyeop Lim et al.· RSC Advances· 0 citations
The SARS-CoV-2 main protease (Mpro) plays a crucial role in viral replication, making it an attractive target for antiviral drug development. This study evaluates the inhibitory potential of nineteen 6-substituted coumarin derivatives (1a–p and 2a–c) against Mpro using a FRET-based enzymatic assay. Among them, the chlo...
Ashraf K. El-Damasy, Md Sofequl Islam Mukim, Sangeun Jeon et al.· RSC Advances· 0 citations
The development of innovative treatment medicines that can overcome drug resistance and intracellular persistence is necessary since tuberculosis (TB) continues to be a significant worldwide health burden. In this work, series of hybrid compounds containing azole moieties, imine/semicarbazide linkers, and isonicotinoyl...
Wagdy M. Eldehna, Zainab M. Elsayed, M. Korycka-Machała et al.· RSC Medicinal Chemistry· 0 citations
A new series of quinazolinone–triazole hybrids (QTHs, 5a–n) was designed, synthesized, and evaluated as potential multi-target-directed ligands for Alzheimer's disease. All synthesized compounds were screened against human monoamine oxidase A (MAO-A) and monoamine oxidase B (MAO-B). The obtained results revealed pronou...
Wagdy M. Eldehna, Ashraf K El-Damasy, Jaeyeop Lim et al.· RSC Advances· 1 citation
The ongoing emergence of SARS-CoV-2 mutations underscores the urgent need for new antivirals that target key viral proteins. This study describes the design, synthesis, and evaluation of two series of 1,3,4-oxadiazole-tethered N-substituted isatin hybrids as inhibitors of the SARS-CoV-2 main protease (Mpro): 1,2,3-tria...
T. Al-Warhi, Md Sofequl Islam Mukim, Zainab M. Elsayed et al.· RSC Advances· 1 citation
This review classifies mutant IDH inhibitors by chemical scaffold and relates their binding in the allosteric pocket to structure-activity trends, isoform selectivity, brain penetration, and clinical outcome.
Moataz A. Shaldam, Anwar A. El-Hamaky, Nourhan A. Khattab et al.· Drug Discovery Today· 0 citations
Chemical 8b may serve as a promising candidate for further anticancer research after demonstrating encouraging dual kinase inhibitory action and exhibiting a favorable selectivity profile for normal MCF-10A cells.
Mohamed El-Naggar, Rofaida Salem, Mona M. Kabeel et al.· Bioorganic & Medicinal Chemi...· 0 citations
The consistent binding of compound 5 d within the ATP‐binding pocket of CDK‐2 was confirmed by molecular docking and molecular dynamics simulations, and attractive drug‐like and pharmacokinetic features, similar to those of Roscovitine, were demonstrated by in silico ADMET predictions.
Wagdy M. Eldehna, Zainab M. Elsayed, Mohamed R. Elnagar et al.· Drug development research (P...· 0 citations
