Author

Wael Elaily

2 papers indexed here

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Open access Sep 2026

Probing the sequence variability tolerance in a de novo α-helical barrel biocatalyst

De novo-designed enzymes have recently achieved high catalytic activity and stereoselectivity while demonstrating exceptional thermostability in entirely novel protein scaffolds. Among these, α-helical barrel protein scaffolds are attractive structures for biocatalysis due to their structural simplicity, high thermosta...

Wael Elaily, Markus Braun, David Stoll et al. · bioRxiv · 0 citations

#protein folding Open access Sep 2026

Computational design of a thermostable α-helical barrel protein with tunable active-site positioning

Over the last decades, transformative catalytic strategies have emerged, with biocatalysis currently exerting a substantial influence on the pharmaceutical and fine chemical sectors. Fast progress in the design of efficient enzymatic processes, however, suffers from the lack of readily available, stable, and customizab...

Wael Elaily, David Stoll, Morakot Chakatok et al. · bioRxiv · 3 citations