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Author

W. Zimmermann

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Open access Sep 2026

Innervated human cardiac muscle model reveals sympathetic drivers of KCNH2-associated arrhythmias

Cardiac autonomic neurons regulate contractility. Autonomic nervous system dysregulation can cause sympathetic overdrive, leading to heart failure, and fatal arrhythmias. Here, we introduce innervated engineered human myocardium (iEHM), a model of neuro-cardiac junctions, constructed by fusing sympathetic neuronal orga...

L. V. Schneider, Michael Gani Setya, Guobin Bao et al. · 0 citations
Open access Jul 2026

SGLT2 inhibition improves sarcomere contractile dysfunction in human models of dilated cardiomyopathy

It is found that a subcellular signaling pathway dysregulated in DCM CMs, clathrin-mediated endocytosis (CME)-dependent signaling, may be recovered by EMP treatment in DCM TPM1-L185F iPSC-CMs, which supports that EMP modulates aspects of CME-signaling, and contributes to restored sarcomere functions.

Daria Plota, H. N. Saleem, K. Lin et al. · 0 citations

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