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Sponsored Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt

Author

W. Schief

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3 papers indexed here

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Aug 2026

Antigen avidity potentiates the durability of the vaccine immune response.

The protective benefits of vaccination can critically depend on the durability of the corresponding immune response. However, the factors influencing vaccine durability are poorly understood. Here, we tested whether antigen avidity (i.e., cumulative multivalent binding strength) affected the durability, magnitude, and...

Nicole G Weidner, Mauricio V. Padilla, Layne Pruitt et al. · 3 citations
Open access Aug 2026

Immunization with mosaic nanoparticles reveals that antigen avidity shapes the clonal hierarchy of the B cell response.

Vaccination with real-world complex antigens often elicits a hierarchical immune response to different epitopes. This immunodominance is a major obstacle in vaccine design because nonprotective epitopes often divert the immune response away from protective epitopes. We posited that B cell epitope avidity (i.e., total m...

Mauricio V. Padilla, Nicole G Weidner, Layne Pruitt et al. · 3 citations
Jul 2026

Germline-targeting vaccine elicits HIV broadly neutralizing antibodies in nonhuman primates 2303354

HIV vaccine development has been exceptionally challenging, for myriad reasons. Nevertheless, protective HIV broadly neutralizing antibodies (bnAbs) exist and have been proposed as templates for vaccine development. Germline-targeting is a conceptually radical approach to vaccine design, aiming to prime rare bnAb...

S. Crotty, Jon M. Steichen, Patrick J. Madden et al. · 0 citations

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