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Open access Sep 2026

Low Molecular Weight Dextran Sulfate Mitigates Acute Kidney Injury Induced by Renal Ischemia/Reperfusion: Implication of JNK/p38 MAPK and Caspase-3

Low molecular weight-dextran sulphate exerts nephroprotective effects against RI/RI by restoring redox balance, suppressing inflammatory signaling, JNK/p38 MAPK, and caspase-3, highlighting its potential as a therapeutic strategy for renal I/R-induced AKI.

Nadrah S. Alamri, Ahlam M. Alhusaini, W. Sarawi et al. · 0 citations
Open access Jul 2026

Involvement of NOD1/NF-κB/MAPK pathway in the protective effect of procyanidin B2 against methotrexate-induced nephrotoxicity

PCB2 reduced oxidative stress and inflammatory responses, indicating potential protective effects against MTX-induced kidney damage and prevented tissue injury and restored the altered parameters.

A. Al Tuwaijri, Ahlam M. Alhusaini, W. Sarawi et al. · 0 citations

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