Author

W. S. Noble

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Open access Oct 2026

Structural variants from donor-specific assemblies affect recurrent chromatin contact divergence in humans

GRAPHICAL ABSTRACT Structural variants (SVs) are a major source of human genetic diversity, yet their contribution to three-dimensional (3D) genome organization remains difficult to resolve using a standard reference genome. Here, we integrate haplotype-resolved chromatin interaction maps across 354 human and 12 nonhum...

L. Ni, Jia-Dong Lin, DongAhn Yoo et al. · bioRxiv · 0 citations

Open access Aug 2026

Cell type-resolved chromatin accessibility clocks for brain aging

A set of cell type-specific and all-cell aging clocks built from snATAC-seq profiles of the prefrontal cortex of 357 human donors, which generalize to accurately predict age across brain regions and species and reveal the regulatory elements, genes, pathways, and motifs underlying these signals across species, disease,...

Patrick Z. Yu, Dou-Dou Yu, Yao Xue et al. · bioRxiv · 0 citations