Open access
Sep 2026
Targeting the YAP‐BST2 Axis Overcomes Intrinsic Anti‐PD‐1 Resistance in Metastatic Gastric Cancer
ABSTRACT Intrinsic resistance to anti‐PD‐1 immunotherapy remains a major obstacle in treating metastatic gastric cancer (GC), particularly in tumors harboring concurrent YAP hyperactivation and TP53 loss. Here, using a genetically engineered mouse model with conditional YAP hyperactivation and Tp53 deletion in gastric...
Wei-Hong Zhang, Shi-Long Wang, Meng Wang et al.
· Advancement of science · 0 citations