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Open access Jul 2026

Quiescent tumor cells shape the immunosuppressive microenvironment in pancreatic cancer

Immunotherapy, including chimeric antigen receptor (CAR) T-cell therapy, has limited activity in pancreatic ductal adenocarcinoma (PDAC). Using orthotopic PDAC mouse models, we identified a rare population of quiescent PDAC cells that increases after CAR-T cell therapy and exhibits relatively higher clonogenic growth a...

B. McClellan, Q. Wang, K. Aung et al. · 0 citations

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