Author

W. Jin

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Review Open access Sep 2026

The nociceptor-CGRP-lactate axis in cancer immune escape: linking neural signaling, immunometabolism, and immunotherapy resistance.

Cancer neuroscience has expanded the conceptual landscape of tumor biology by revealing that nerves are not passive bystanders within malignant tissues, but active regulators of tumor progression, immune surveillance, and therapeutic response. Among neural components of the tumor microenvironment, nociceptive sensory n...

Peng-Yu Zhao, Kun Wu, Zi-Xiang Jin et al. · Pharmacological Research · 0 citations

Open access Sep 2026

Tumor-derived MG53 aggravates gastrointestinal cancer cachexia related muscle atrophy by inhibiting the TLR4/PI3K/AKT/FOXO3a signaling pathway

MG53 correlates with muscle atrophy, supporting its potential as a diagnostic biomarker and therapeutic target of gastrointestinal cancer cachexia and its potential as a diagnostic biomarker and therapeutic target of cancer cachexia.

Yong-Fei Wang, Yuan-Yuan Xin, Si-Yuan Wang et al. · Frontiers in Oncology · 0 citations

Review Open access Sep 2026

Heterogeneity in cancer: molecular mechanisms and therapeutic strategies

The Holistic Integrative Tumor Ecosystem Theory (HITET) is proposed, a five-dimensional framework connecting these scales through functional interfaces that synthesizes how genetic alterations, cellular plasticity, metabolic programs, immune and stromal interactions, spatial gradients, organ-specific environments, micr...

Yong-Lin He, Liang Niu, Yan-Ming Ren et al. · Signal Transduction and Targ... · 0 citations