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Open access Sep 2026

A combined program of induced stemness and differentiation in response to IFNγ drives acute myeloid leukaemia growth

How inflammation shapes acute myeloid leukaemia (AML) has come under scrutiny, as it may explain the disease’s resistance to immunotherapy approaches. IFNγ has emerged as a key cytokine with paradoxical roles in suppressing and supporting AML growth, and the fundamental question of how leukemic stem cells (LSCs) respon...

C. Pospori, A. Donada, Helena Boutzen et al. · 0 citations
Aug 2026

Myofibrillar myopathy-associated KY protein promotes muscle fibre size rescue independent of its predicted catalytic triad.

The data suggests that the TGN/PROT domain facilitates critical molecular associations at the sarcomeric Z-disc through a mechanism independent of catalysis and that impaired autophagic flux may contribute to the muscle phenotype.

Ahmed Nouh, Oscar Harrad, A. M. Brzozowski et al. · 0 citations

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