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Author

W. Deeksha

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Open access Oct 2026

Identification of Novel Enzymes Regulating ADP-Ribosylation of Uracil and Thymine in Nucleic Acids.

ADP-ribosylation (ADPr) is a conserved modification that regulates a wide range of cellular processes. Although proteins are the best-characterized substrates of ADPr, recent studies have demonstrated that nucleic acids can also be modified. However, the enzymes responsible for installing and removing nucleic acid ADPr...

Yang Lu, W. Deeksha, Kang Zhu et al. · 0 citations
Jul 2026

Deciphering the Specificity of Reversible DNA-Phosphate ADP-Ribosylation via the Precise Synthesis and Enzymatic Profiling of Nucleotide-Phospho-ADP-Ribosyl Probes.

The stereoselective synthesis of deoxynucleotide-phospho-ADPr (dN-P-ADPr) probes are reported, representing native fragments of terminal DNA-ADPr, showing that these enzymes exhibit an absolute preference for the native-like α-anomer, independent of the identity of the adjacent DNA nucleobase, suggesting that substrate...

Lingxiao Liu, Yang Lu, Zongxing Yu et al. · 0 citations

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