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Open access Oct 2026

Association of cumulative triglyceride-glucose index with incident metabolic dysfunction-associated steatotic liver disease: a cohort study

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a growing global public health burden with progressive hepatic and cardiometabolic consequences. Insulin resistance is central to MASLD pathogenesis, and the triglyceride-glucose (TyG) index is a practical surrogate marker for insulin resistance...

S. Kang, N. Zhang, W. Chen et al. · 0 citations
Open access Oct 2026

Biological age acceleration and progression of cardiovascular-kidney-metabolic syndrome: a multi-cohort comparative analysis of phenoage and KDMAge

Accelerated biological aging was robustly associated with advanced CKM across all populations, with PhenoAge consistently outperforming KDMAge, and PhenoAge demonstrated superior risk stratification capability compared to KDMAge, highlighting its potential utility in early risk assessment.

Y. Chen, W. Li, W. Chen et al. · 0 citations
Open access Oct 2026

Relationship between cumulative exposure to systemic inflammation response index and risk of all-cause mortality in middle-aged and older adults with cardiovascular-kidney-metabolic syndrome stage 0–2

The systemic inflammation response index (SIRI) was associated with higher risk of mortality in individuals with Cardiovascular-Kidney-Metabolic (CKM) syndrome stages 0–2. However, the long-term effect of high SIRI on all-cause mortality risk remains unclear in middle-aged and elderly individuals with CKM syndrom...

X. Liu, W. Chen, Y. Chen et al. · 0 citations

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