Open access
Jul 2026
Synaptic plasticity deficits via aberrant engagement of metaplasticity in the hippocampus of PS19 mice
It is demonstrated that transregional metaplasticity, as driven by prior activity in the stratum oriens (SO) in a way that inhibits subsequent LTP in wild-type mice, is occluded in PS19 mice, suggesting that the tauopathic hippocampus exists in a “metaplastic” state, which inhibits future LTP.
Shruthi Sateesh, B. Logan, O. Jones et al.
· bioRxiv · 0 citations