Author

W. Barra

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Open access Oct 2026

Induced mismatch repair deficiency: a hypothesis for the transient and reversible sensitization of mismatch repair-proficient tumors to Immune checkpoint blockade

Immune checkpoint blockade (ICB) has transformed the treatment landscape of multiple malignancies, producing durable responses and long-term survival in subsets of patients with advanced cancer. However, the clinical benefit of ICB remains largely restricted to tumors displaying pre-existing immune activation, high tum...

P. Assumpção, A. Leal, W. Barra et al. · Frontiers in Immunology · 0 citations

Open access Oct 2026

Post-neoadjuvant therapy lymph node response in patients with gastric adenocarcinoma

ABSTRACT Background: Neoadjuvant chemotherapy is recommended as the standard of care for eligible patients with locally advanced resectable gastric adenocarcinoma. However, given the often-late diagnosis of this tumor, understanding post-neoadjuvant therapy lymph node involvement remains a determining factor in the pro...

G. Ishak, Luciana Roberta Do Vale Corrêa, Thaygo de Azevedo Neves et al. · Arquivos Brasileiros de Ciru... · 0 citations

Open access Aug 2026

Coexpression network analysis of gastric adenocarcinoma identifies hub genes as biomarker candidates and their tumor microenvironment associations

Abstract Gastric adenocarcinoma (GAC) is characterized by molecular heterogeneity that limits early detection and targeted treatment. We applied weighted gene coexpression network analysis (WGCNA) to paired RNA-seq data from 119 GAC and peritumoral tissue (PTT) samples and identified six coexpression modules with disti...

Ronald Matheus da Silva Mourão, Fabiano Cordeiro Moreira, J. M. Costa da Silva et al. · Genetics and Molecular Biolo... · 0 citations