BACKGROUND
Loss of blood-brain barrier (BBB) integrity is observed in patients with hypertension and is hypothesized to contribute to cerebral small vessel disease (SVD) pathogenesis. Blood pressure increase and decrease within individuals and the effects on BBB integrity have never been examined.
OBJECTIVES
To exami...
Esther Janssen, J. D. de Jong, E. Verburgt et al.· Journal of Hypertension· 0 citations
Disentangling P and S from the BBB leakage rate provides two biologically more specific and interpretable measures, which have counteracting effects on the BBB leakage in aging and disease.
Damon Verstappen, J. D. de Jong, P. Voorter et al.· Journal of Cerebral Blood Fl...· 0 citations
Ventral, medial, and posterior nuclei metrics show promise as imaging biomarkers of disease burden and seizure severity, thus encouraging further research into both structural and functional properties of thalamic nuclei in focal epilepsy.
D. Uher, L. Vermeer, J. Jansen et al.· Neuroradiology· 0 citations
WMH burden followed an exponential trajectory across Fazekas scores, with population-dependent progression, facilitating cross-study comparison, large-scale epidemiology, and might facilitate clinical decision-making in cerebral small vessel disease.
Yu-Yuan Xu, Francesca M. Chappell, Maria D. Valdes-Hernandez et al.· Stroke· 0 citations
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