W. Aronow

Echocardiographic estimates of pulmonary artery acceleration time and mortality risk in older adults.

BACKGROUND Pulmonary artery acceleration time (PAAT) is an echocardiographic measure associated with pulmonary artery pressure. Although reduced PAAT has been linked to pulmonary hypertension and adverse outcomes in selected patient populations, less is known about its prognostic significance in community-dwelling olde...

Toxic Metal-Essential Trace Element Imbalance in Cardiometabolic Disease: Ferroptosis as a Mechanistic Link Between Environmental Exposure and Vascular Injury

Pediatric Hyperlipidemia Guidelines: A Comprehensive Review of Screening, Diagnosis, and Management.

Atherosclerotic cardiovascular disease originates in childhood, and cumulative exposure to low-density lipoprotein cholesterol (LDL-C) is a major determinant of lifetime cardiovascular risk. Multiple professional societies have published guidelines for lipid screening, diagnosis, and management in pediatric populations...

Complete Revascularization Versus Culprit-Only Percutaneous Coronary Intervention in Non-ST-Elevation Myocardial Infarction With Multivessel Disease: A Nationwide Propensity Score-Matched Analysis.

We used the National Inpatient Sample from 2016 to 2022 to compare complete revascularization with culprit-only percutaneous coronary intervention in adults hospitalized with non-ST-elevation myocardial infarction and multivessel disease. Hospitalizations complicated by cardiogenic shock, cardiac arrest, coronary arter...

Menopausal Hormone Therapy and Cardiovascular Risk: Current Evidence and Treatment Recommendations.

In 2025, the US Food and Drug Administration (FDA) removed its prior class-wide boxed warnings for menopausal hormone therapy (MHT), paving the way for increased clinical use. Menopause accelerates cardiovascular risk independently of chronological aging, manifesting as a 7.5% increase in carotid-femoral pulse wave vel...

Cardiorenal Syndrome in Cardiogenic Shock: Contemporary Pathophysiology, Hemodynamic Principles, and Emerging Therapeutic Strategies.

Cardiorenal syndrome (CRS) represents a complex bidirectional interaction between the heart and kidneys whereby acute or chronic failure of one organ precipitates dysfunction in the other. CRS occurring in the setting of cardiogenic shock (CS), or CRS-CS, remains one of the most severe manifestations, contributing subs...

Osimertinib-Associated Cardiotoxicity in EGFR-Mutant Non-Small Cell Lung Cancer: Mechanisms, Phenotypes, and Surveillance.

Osimertinib, a third-generation EGFR-TKI, is now the standard first-line treatment for EGFR-mutant non-small cell lung cancer and is increasingly given in the adjuvant setting for up to 3 years and in combination with chemotherapy. As exposure has lengthened and shifted toward curative-intent settings, its cardiac effe...

Cardiac Myosin-Binding Protein C in Cardiovascular Disease.

An overview of the molecular biology and physiologic functions of cMyBPC is provided and its role in HCM, myocardial injury, and other forms of cardiovascular disease is examined.

Protecting the Aging Brain in Diabetes: Mechanism, Biomarkers, and Emerging Therapeutic Frontiers in Cognitive Impairment-A Comprehensive Review.

A systematic literature search was executed across PubMed, MEDLINE, Embase, and PsycINFO utilizing MeSH terms such as "type 2 diabetes mellitus," "cognitive decline," "dementia," "insulin resistance," "neuroinflammation," and "neuroprotection," to synthesize evidence across the mechanisms, biomarkers, and therapeutic a...

Efficacy and Safety of Ongericimab in Patients With Dyslipidemia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials With GRADE Assessment.

Ongericimab is a humanized monoclonal antibody against proprotein convertase subtilisin/kexin type 9 that reduces LDL-C and increases apolipoprotein A1 and high-density lipoprotein cholesterol and increased apolipoprotein A1 and high-density lipoprotein cholesterol (all P < 0.0001).

Efficacy and Safety of Selective Aldosterone Synthase Inhibitors in Uncontrolled Hypertension: A Systematic Review and Dose-Specific Network Meta-Analysis of Randomized Controlled Trials.

Selective aldosterone synthase inhibitors (ASIs), including baxdrostat and lorundrostat, target CYP11B2 while sparing cortisol synthesis, offering a novel strategy for resistant and uncontrolled hypertension. Yet existing meta-analyses have included nonselective agents or omitted the latest phase 3 data. We searched Pu...

Left Atrial Strain Impairment in Embolic Stroke of Undetermined Source: A Systematic Review and Meta-Analysis.

Evidence on all 3 LA strain phases in ESUS through July 2026 supports subclinical atrial cardiomyopathy as an embolic substrate independent of atrial fibrillation.