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W. Andō

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Open access Sep 2026

Identification of Key Amino Acid Residues in the Adenylation Domains of Polymyxin Synthetase Responsible for l‑Threonine Adenylation in Paenibacillus polymyxa NBRC3020

This study investigated two l-threonine (l-Thr)-specific A domains from the NRPS responsible for polymyxin D biosynthesis in Paenibacillus polymyxa NBRC 3020, and identified three residues within the 10-amino-acid Stachelhaus codePhe, Met, and His as key determinants of l-Thr side-chain recognition.

W. Andō, Yuya Uemura, Mai Nemoto et al. · 0 citations

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