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W. Aboulthana

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Open access 2026

Synthesis and therapeutic evaluation of isatin-linked pyrazole motif derivatives

Multi-target drugs possess significant therapeutic potential for the therapy of complex diseases and drug-resistant conditions. Based on this fact, isatin-pyrazole derivatives, namely, 5-substituted isatin-pyrazole derivatives 7a-d and N-alkyl isatin-pyrazole derivatives 9a-d, were prepared by merging the pyrazole moti...

Mohamed A. Al-Omar, H. Alkahtani, M. A. Bhat et al. · 0 citations
Open access Aug 2026

Development of new imidazopyridine-based chalcones hybrids as potent antidiabetic and antioxidant agents: synthesis, in silico and in vitro evaluation

A novel series of six imidazopyridine-based chalcone hybrids is synthesized and evaluated their in vitro biological activities, including total antioxidant capacity, iron-reducing power, and radical scavenging (DPPH, ABTS, NO), as well as antidiabetic potential against α-amylase, α-glucosidase, and aldose reductase.

Hanan Abdelmawgoud Atia, Aladdin M. Srour, Hanaa Farag et al. · 0 citations

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