Abstract A048: TGFBR2 dysfunction rewires cell cycle, MAPK signaling, and migration in pancreatic cancer
Genetically engineered mouse models of PDAC exhibit marked differences in survival, indicating that certain genetic alterations regulate disease progression. KC (Ptf1a Cre/+; LSL-Kras G12D/+) mice that possess wildtype transforming growth factor-beta receptor 2 (TGFBR2) have a median survival of 13 months, wherea...