Author

Vijay Ramani

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Open access Oct 2026

SETDB1 preferentially silences evolutionarily young retroelements.

Transposable elements (TEs) are epigenetically silenced through multiple mechanisms, including heterochromatin formation and DNA methylation. Prior studies have implicated SETDB1 and the Human Silencing Hub (HUSH) complex in heterochromatin formation-based TE repression, but precise characterization of repeat subclass...

Bercin K. Cenik, Si-Mai Wang, Marta Iwanaszko et al. · Proceedings of the National... · 0 citations

Open access Aug 2026

Maintenance of nucleosome organization through replication and transcription counteracts aberrant coalescence of active chromatin.

Nucleosomes with their associated modifications organize and regulate the genome. It is unclear how this is integrated with the requirement of replication and transcription to access the DNA template without jeopardizing chromatin function. Here, we reveal a unified requirement for the histone chaperone FACT in mediati...

R. C. M. Frater, Rikke Rejnholdt Jensen, Joaquim Ollé López et al. · Molecules and Cells · 0 citations