Author

Victoriano Mulero

2 papers indexed here

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Open access Oct 2026

A zebrafish model of NEXMIF-related encephalopathy identified drivers of hyperlocomotion and provides a scalable platform for drug discovery

X-linked Intellectual Disability type 98 (XLID-98) is a neurodevelopmental disorder with a broad phenotypic spectrum caused by pathogenic variants in the neurite extension and migration factor ( NEXMIF ) gene, formerly known as KIAA2022, KIDLIA , or XPN (OMIM 300524). To investigate the pathogenic mechanisms of...

Beatriz Bernal-Bermúdez, Francisco J. Martínez-Morcillo, Inmaculada Fuentes-Martínez et al. · Frontiers in Cell and Develo... · 0 citations

Open access Sep 2026

Stabilization of the PP2A-B56α complex overcomes venetoclax-azacitidine resistance by impairing OXPHOS in AML.

Cell metabolic rewiring is associated with resistance to venetoclax-azacitidine (Ven-Aza) combination therapy and relapse in acute myeloid leukemia (AML) patients. Drug-resistant cells exhibit an enhanced reliance on oxidative phosphorylation (OXPHOS) for energy production. Therefore, impairing mitochondrial metabolism...

Silvia Romero-Murillo, I. Peris, A. Lucianò et al. · JCI Insight · 0 citations