Review
Open access
Sep 2026
A microprotein atlas of the human frontal cortex in Alzheimer’s disease
Understanding the molecular basis of neurodegeneration requires a comprehensive map of the genome’s protein-coding output. Although thousands of small open reading frames (ORFs) are translated in the human brain, proteomic evidence for their encoded microproteins (MPs) (≤150 amino acids (aa)) remains limited. Here, we...
Brendan Miller, Eduardo Vieira de Souza, Calvin J. Lau et al.
· Nature Aging · 1 citation