Author

Veronica Ruggieri

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Open access Sep 2026

KDM6A loss enhances oxidative phosphorylation uncovering tissue-level convergent evolution

The tumor suppressor KDM6A/UTX, a histone demethylase and a 2-oxoglutarate-dependent dioxygenase, is frequently lost in many cancer types. We show that KDM6A loss pervasively activates oxidative phosphorylation in several solid tumors, generating a pseudo-hyperoxic environment, opposite from the pseudo-hypoxia observed...

Antonino Alex Cartalemi, D. Rosano, Camilla Ferrari et al. · EMBO Journal · 0 citations

Open access Aug 2026

Comprehensive transcriptomic profiling reveals impaired polyamine metabolism as a contributor to age-related muscle decline

A spatial transcriptomic atlas of skeletal muscle from young and aged mice is presented, resolving transcriptional reprogramming across fiber types and tissue compartments and revealing alterations in sarcomeric organization, excitation-contraction coupling, oxidative stress responses, and fiber type-specific metabolic...

Veronica Ruggieri, Andrea Bracaglia, Lorenza Esposito et al. · iScience · 0 citations